Fibrillarin 抗体
Quick Overview for Fibrillarin 抗体 (ABIN7114191)
抗原
See all Fibrillarin (FBL) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- FBL antibody
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纯化方法
- Immunogen affinity purified
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纯度
- ≥95 % as determined by SDS-PAGE
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免疫原
- fibrillarin
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亚型
- IgG
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应用备注
- WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:20 - 1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- -20 °C
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储存方法
- -20°C for 12 months
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有效期
- 12 months
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- Fibrillarin (FBL)
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别名
- FBL
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背景
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Synonyms: rRNA 2'-O-methyltransferase fibrillarin|34 kDa nucleolar scleroderma antigen|Histone-glutamine methyltransferase|U6 snRNA 2'-O-methyltransferase fibrillarin|FBL|FIB1|FLRN
Background: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.
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分子量
- 37 kDa
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基因ID
- 2091
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UniProt
- P22087
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途径
- Ribonucleoside Biosynthetic Process
抗原
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